DEPARTMENT OF IMMUNOLOGY



Tchavdar Vassilev

Tchavdar Vassilev, DSc, Professor
Head of Department
Tel: (359 2) 979-31-17
E-mail: vassilev@microbio.bas.bg

1950      Born, December 16 in Sofia
1974 MD, Sofia Medical School
1978 Ph.D degree in Immunology, Medical Academy, Sofia
1996 D.Sc.,Institute of Microbiology, Bulgarian Academy of Sciences
1998 Professor of Immunology, Institute of Microbiology, BAS
1999 Visiting Scientist, Princeton University, New Jersey
2000 Head, Department of Immunology, Institute of Microbiology, BAS




Hristo Neychev

Hristo O. Neychev,
PhD, Assoc. Professor
Head of Research Team
Tel: (359 2) 979-31-81
E-mail: neychev@microbio.bas.bg
1947      Born October 10, Kazanlak
1973 Diploma, High Veterinary Medical School, Sofia
1974 Assistant Professor Institute of Microbiology
1982 PhD in Microbiology, Institute of Microbiology, BAS
1982 Specialization in the Institute of Immunology, Wien, Austria
1988 Associate Professor, Institute of Microbiology
1989-2000       Head, Department of Immunology, Institute of Microbiology, BAS




Emilia Ivanova

Emilia Ivanova
PhD, Assoc. Professor
Head of Research Team
Tel: (359 2) 979-31-84
E-mail: eivanova@microbio.bas.bg
1940      Born August 30, Biala Slatina
1964 MD, Sofia Medical School
1970 Ph.D, Veterinary Institute of Infectious and Parasitic Diseases, Sofia
1976 Scientist, Institute of Microbiology, BAS
1979 Associate Professor, Institute of Microbiology, BAS




Main Research Topics:

Most Important Achievements

Projects

      Grant from Howard Hughes Medical Institute (2001-2005)
      Project leader: Prof. Tchavdar Vassilev, DSc

      Leonardo da Vinci project for vocational training "Open and Distance Learning in Healthcare Microbiology and Immunology" (2001 - 2003)
      Coordinator:Assoc. Prof. Hristo Neychev


Selected Publications

      Mannhalter, J., H. Neychev, G. Zlabinger, R. Ahmad, M. Eibl. Modulation of the human response by the non-pyrogenic adjuvant aluminium hidroxide: Effect on antigen uptake and antigen presentation. Clin. Exp. Immunol., 1985, 61, 143-151.

      Neychev, H., V. Lambov, A. Kujumdjieva, E. Slavcheva. Effect of Polysaccharides produced by Rhodotorula glutinis on the number and attachment to glass of peritoneal macrophages. Adv. Biosci., 1988, 68, 285-289.

      Kenarova, B., H. Neychev, C. Hadjiivanova, V. Petkov. Immunomodulating activity of Gensenoside RG1 from Panax Ginseng. Japan J. Pharmacology, 1990, 54, 447-454.

      Neychev, H., N. Ivanovska, V. Valeva, Z. Stefanova, A. Kujumdjieva. Antiinflammatory effect of Superoxide Dismutase (SOD). Comparison between yeast and bovine SOD on some complement-mediated reactions in vitro and in vivo. Int. J. Tissue Reaction., 1994, XVI (3), 131-137.

      Valeva, V., Z. Stefanova, I. Yanchev, H. Neychev. Influence of liposome-encapsulated yeast Cu/Zn Superoxide Dismutase on the phagocytosis of mouse peritoneal-exudation cells. C.R. Acad. Bulg. Sci., 1994, 47(7), 83-86.

      Stefanova, Z., H. Neychev, N. Ivanovska, I. Kostova. Effect of total extract and esculin from Fraxinus ornus stem bark on zymosan and carragenan induced paw oedema in mice. J. Ethnopharmacology, 1995, 46, 101-106.

      Ivanovska, N., H. Neychev, Z.Stefanova, V.Bankova, S.Popov. Influence of cinnamic acid on lymphocyte proliferation, cytokine release and Klebsiella pneumoniae infection in mice. Apidologie, 1995, 26, 73-81.

      Ivanovska, N., H. Neychev, P. Georgieva, R. Barrot-Ciorbarru. Modulation of complement activity by Nocardia lyzosyme digest (NLD). Int. J. Immunopathol. Pharmacol., 1996, 9(3), 113-117.

      Baykov, B., M. Gugova, M. Stoyanov, H. Neychev, Z. Stefanova, N. Nikolova. Designing an artificial ecological mesocosm for the study of Cd and Pb impact on the immune system of experimental animals. Toxicology Letters, 1996, 89, 5-10.

      Ivanova, E. H., L. Michailova, Z. Stefanova, H. Neychev, S. Radoevska, J. Gumpert. Effect of Escherichia coli L-form cytoplasmic membranes on the interaction between macrophages and Lewis lung carcinoma cells: scanning electron microscopy. FEMS Immunol. Med. Microbiol., 1997, 17, 27-36.

      Stefanova, Z., N. Nikolova, T. Dimov, Y. Michailov, H. Neychev. Effect of Oxadin on phagocytosis and hydrogen peroxide production. Pharmazie, 1997, 52(5), 409-410.

      Ratcheva, I., Z, Stefanova, A. Vesselinova, S. Nikolova, H. Neychev. Treatment of adjuvant arthritis in mice with yeast superoxide dismutase. Pharmazie, 2000, 55, 533-537.

      Ratcheva, I., Z. Stefanova, A Vesselinova, S. Nikolova, H. Neychev. Influence of yeast superoxide dismutase on tissue inflammation during adjuvant-induced arthritis in mice. C.R. Acad. Bulg. Sci., 2000, 53(9), 85-88.

      Ivanova, E., L. Michailova, Z. Stefanova, H. Neychev, S. Radoevska, J. Gumpert. Effect of Escherichia coli L-form cytoplasmic membranes on the interaction between macrophages and Lewis lung carcinoma cells: scanning electron microscopy. FEMS Immunol. Med. Microbiol., 1997, 17(1), 27-36.

      Ivanova, E., I. Yanchev, N. Najdenski, R. Toshkova, P. Dimitrova, V. Manov. Studies on the interactions of immunostimulated phagocytes and Yersinia enterocolityca O:8 cells. Can. J. Microbiol., 2000, 46(3), 218-228.

      Ivanova, E., R. Toshkova. Immunoprotective activity of Listeria monocytogenes L-form cytoplasmic membranes. Exper. Oncology, 1999, 21(1), 24-30.

      Toshkova, R.A., P.A. Dimitrova, E.H. Ivanova, P.A. Dolashka, M.B . Angelova, S.B. Pashova, W. Voelter. Immunoprotective effect of Humicola lutea superoxide dismutase on myeloid Graffi tumor bearing hamsters. Z. fur Naturforshung, 2000, 55, 649-656.

      Vassilev, Tch., I. Bineva, G. Dietrich, S.-V. Kaveri, M. Kazatchkine. Variable region-connected, dimeric fraction of intravenous immunoglobulin enriched in natural autoantibodies. J. Autoimmun., 1995, 8, 405-413.

      Kaveri, S., M. Kazatchkine, T.Vassilev. Autoimmunitaet an der Grenze zur Autoaggression. Immunomodulierende Effecte von IVIG auf eine gestorte Immunhomoostase. Aspekte im Gespraech, 1996, 4, 9-17.

      Kaveri, S., T. Vassilev, V. Hurez, et al. Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use (IVIg). J. Clin. Investig., 1996, 97, 865-869.

      Vassilev, T., K. Veleva. Natural polyreactive IgA and IgM autoantibodies in human colostrum. Scand. J. Immunol., 1996, 44, 535-539.

      Vassilev, T., M. Kazatchkine. Mechanisms of immunomodulatory action of intravenous immunoglobulin in autoimmune and systemic inflammatory diseases. Therapeutic Apheresis, 1997, 1, 38-41.

      Vassilev, T., V. Hurez, A. Pashov, C. Dubey, S. Lacroix-Desmazes, B. Bellon, M. Kazatchkine, S. Kaveri. Interactions of intravenous immunoglobulin with molecules and cells of the immune system. In:, M.Kazatchkine and A.Morell (Eds.) Intravenous Immunoglobulin - Research and Therapy. Parthenon Publ., London, 1996, 95-102.

      Vassilev, T., S. Lacroix-Desmazes, A. Pashov, M. Kazatchkine, S. Kaveri. Treatment with intravenous immunoglobulin delays the expression of CD69 on T cells in hu-PBL-SCID mice. In: M.Kazatchkine and A.Morell (Eds.) Intravenous Immunoglobulin - Research and Therapy. Parthenon Publ., London, 1996,319-320.

      Kaveri, S., N. Prasad, T. Vassilev et al. Modulation of autoimmune responses by intravenous immunoglobulin (IVIg). Multiple Sclerosis, 1997, 3, 121-128.

      Vassilev, T., G. Dimov, S. Marinova, et al. An IgA, IgG and IgM-containing human immunoglobulin for oral administration to high-risk bottle-fed newborns. I. Immunochemical characterisation and antibody activity. Int. J. Hematol., 1997, 65, 277-283.

      Hurez, V., M. Kazatchkine, T. Vassilev, S. Ramanathan, B. Basuyaux, A. Pashov, Y. De Kozak, B. Bellon, S. Kaveri. Pooled normal human polyspecific IgM contains neutralysing antiidiotypes to IgG autoantibodies of autoimmune patients and protects from autoimmune diseases. Blood, 1997, 90, 4004-4013.

      Vassilev, T. Immunoglobulin Therapy (a Monograph in Bulgarian), Znanie Publishers., Sofia 1999, 119.

      Vassilev, T. L. Kazatchkine, M.D. J.-P. Van Huen, M. Mekrache, E. Bonnin, J.-C. Mani, C. Lecroubier, D. Korinth, D. Baruch, F. Schriever, S.K. Kaveri. Inhibition of cell adhesion by antibodies to Arg-Gly-Asp (RGD) in normal immunoglobulin for therapeutic use (intravenous immunoglobulin, IVIg). Blood, 1999, 93, 3624-3631.

      Vassilev, T., M. Yamamoto, A. Aissaoui, E. Bonnin, S. Berrih-Aknin, M. Kazatchkine, S.K. Kaveri. Normal human immunoglobulin suppresses experimental myasthenia gravis in SCID mice. Eur. J. Immunol., 1999, 29, 2436-2442.

      Vassilev, T. Physiological self-reactivity or autoaggression? (A Monograph in Bulgarian), Academy of Sciences Press, Sofia, 2000 (In press).

      Georgieva, P, N. Ivanovska, R. Barot-Ciorbaru. Immunomodulatory properties of Nocardia lysozyme digest (NLD) in complement normal and C5- defficient mice, Vaccine. 1998, 16, 1237-1242.

      Ivanovska, N., S. Philipov, M. Hristova. Influence of berberine on T-cell mediated immunity. Immunopharmacol. Immunotoxicol., 1999, 21(4), 771-786.

      Ivanovska, N., M. Hristova, S. Philipov. Immunosuppression and recovery of drug-impaired host resistance against Candida albicans infection by oxoglaucine. Pharmacol. Res., 2000, 41(1), 99-105.

      Ivanovska, N., M. Hristova. Treatment with oxoglaucine can enhance host resistance to Candida albicans infection of mice with adjuvant arthritis. Diagn. Microbiol. Infect. Dis., 2000, 38, 17-20.

      Ivanovska, N. Protective effect of Nocardia lysozyme digest (NLD) in murine Candida albicans infections. Medical Mycology, 2001, 39, 221-227.